Volume 06,Issue 04

The Estrogen Receptor and Breast Cancer: A Complete Review

Authors

Mozhgan Sarhadi, Leila Aryan, Mehdi Zarei

Abstract
Estrogens play an important role in normal breast development as well as breast cancer progression. Most of the effects of estrogen are mediated through its two receptors: estrogen receptor α (ERα) and β (ERβ). Both ERα and ERβ are intracellular nuclear hormone receptors and mediate estrogen signaling primarily through transcriptional activation of target genes. Estrogen is an essential hormone for mammary gland development and reproductive organ function. Estrogen also regulates other diverse physiological functions associated with the cardiovascular, central nervous, immune, and skeletal systems. This review will summarize the current body of knowledge on ERα and ERβ in cancer. Clinical correlations between estrogen receptors have also been reported. Thus, this review will discuss the estrogen receptors signaling pathways.

Keyword: Estrogens, breast cancer, receptors, mammary gland.

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